One major difference for me in Florence when compared to Milan... is how picturesque Florence is. Milan is more of a business city... lots of cement... less of the gorgeously detailed architecture. Just walking through the city is extremely enjoyable and is a great way to 'see the sights'. When I walk through Milan, I love the city and enjoy living in Milan!... but I feel like I walk more just to get from one destination to the next.
Florence is cute. : )